Welcome to the Lin Lab
​
  • Home
  • About
  • People
  • Research
  • Publications
  • Positions Available
  • Contact
  • Donate
Picture

Peer-Reviewed Publications as of 12/17/2020

Wu CY, Couto E Silva A, Citadin CT, Clemons GA, Acosta CH, Knox BA, Grames MS, Rodgers KM, Lee RH, Lin HW. Palmitic acid methyl ester inhibits cardiac arrest-induced neuroinflammation and mitochondrial dysfunction. Prostaglandins Leukot Essent Fatty Acids. 2021 Feb;165:102227. doi: 10.1016/j.plefa.2020.102227. Epub 2020 Dec 17. PubMed PMID: 33445063; NIHMSID:NIHMS1661898.

Lee RH, Grames MS, Wu CY, Lien CF, Couto E Silva A, Possoit HE, Clemons GA, Citadin CT, Neumann JT, Pastore D, Lauro D, Della-Morte D, Lin HW. Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest. Am J Physiol Heart Circ Physiol. 2020 Nov 1;319(5):H1044-H1050. doi: 10.1152/ajpheart.00399.2020. Epub 2020 Sep 18. PubMed PMID: 32946263.

Chen PY, Wu CY, Clemons GA, Citadin CT, Couto E Silva A, Possoit HE, Azizbayeva R, Forren NE, Liu CH, Rao KNS, Krzywanski DM, Lee RH, Neumann JT, Lin HW. Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest. Prostaglandins Leukot Essent Fatty Acids. 2020 Aug;159:102138. doi: 10.1016/j.plefa.2020.102138. Epub 2020 May 23. PubMed PMID: 32663656.

Wu CYC, Lopez-Toledano MA, Daak AA, Clemons GA, Citadin CT, Sancilio FD, Rabinowicz AL, Minagar A, Neumann JT, Lee RHC, Lin HW. SC411 treatment can enhance survival in a mouse model of sickle cell disease. Prostaglandins Leukot Essent Fatty Acids. 2020 Jul;158:102110. doi: 10.1016/j.plefa.2020.102110. Epub 2020 May 3. PubMed PMID: 32447175.

Couto E Silva A, Wu CY, Citadin CT, Clemons GA, Possoit HE, Grames MS, Lien CF, Minagar A, Lee RH, Frankel A, Lin HW. Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function. Mol Neurobiol. 2020 Mar;57(3):1716-1732. doi: 10.1007/s12035-019-01850-z. Epub 2019 Dec 10. Review. PubMed PMID: 31823198; PubMed Central PMCID: PMC7062579.

Lee RH, Couto E Silva A, Possoit HE, Lerner FM, Chen PY, Azizbayeva R, Citadin CT, Wu CY, Neumann JT, Lin HW. Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest. Prostaglandins Leukot Essent Fatty Acids. 2019 Aug;147:6-14. doi: 10.1016/j.plefa.2018.11.011. Epub 2018 Nov 23. PubMed PMID: 30514597; PubMed Central PMCID: PMC6533160.

Lee RHC, Lee MHH, Wu CYC, Couto E Silva A, Possoit HE, Hsieh TH, Minagar A, Lin HW. Cerebral ischemia and neuroregeneration. Neural Regen Res. 2018 Mar;13(3):373-385. doi: 10.4103/1673-5374.228711. Review. PubMed PMID: 29623912; PubMed Central PMCID: PMC5900490.

Wu CYC, Lerner FM, Couto E Silva A, Possoit HE, Hsieh TH, Neumann JT, Minagar A, Lin HW, Lee RHC. Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest. J Vis Exp. 2018 Jan 5;(131). doi: 10.3791/56694. PubMed PMID: 29364254; PubMed Central PMCID: PMC5908446.

Lee RH, Couto E Silva A, Lerner FM, Wilkins CS, Valido SE, Klein DD, Wu CY, Neumann JT, Della-Morte D, Koslow SH, Minagar A, Lin HW. Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia. Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H182-H188. doi: 10.1152/ajpheart.00482.2016. Epub 2016 Nov 18. PubMed PMID: 27864234.

Lee RC, Goyanes Vasquez JJ, Couto e Silva A, Klein DD, Valido SE, Chen JA, Lerner FM, Neumann JT, Wu CY, Lin HW. Fatty acid methyl esters as a potential therapy against cerebral ischemia. Oilseeds and fats Crops and Lipids. 2015 October; 23(1):D108. doi: http://dx.doi.org/10.1051/ocl/2015040.

Cohan CH, Neumann JT, Dave KR, Alekseyenko A, Binkert M, Stransky K, Lin HW, Barnes CA, Wright CB, Perez-Pinzon MA. Effect of cardiac arrest on cognitive impairment and hippocampal plasticity in middle-aged rats. PLoS One. 2015;10(5):e0124918. doi: 10.1371/journal.pone.0124918. eCollection 2015. PubMed PMID: 25933411; PubMed Central PMCID: PMC4416883.

Lin HW, Gresia VL, Stradecki HM, Alekseyenko A, Dezfulian C, Neumann JT, Dave KR, Perez-Pinzon MA. Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest. J Cereb Blood Flow Metab. 2014 Apr;34(4):613-20. doi: 10.1038/jcbfm.2013.232. Epub 2014 Jan 22. PubMed PMID: 24447953; PubMed Central PMCID: PMC3982078.

Lin HW, Saul I, Gresia VL, Neumann JT, Dave KR, Perez-Pinzon MA. Fatty acid methyl esters and Solutol HS 15 confer neuroprotection after focal and global cerebral ischemia. Transl Stroke Res. 2014 Feb;5(1):109-17. doi: 10.1007/s12975-013-0276-z. Epub 2013 Aug 6. PubMed PMID: 24323706; PubMed Central PMCID: PMC3948321.
select
Lin HW, Perez-Pinzon M. The role of fatty acids in the regulation of cerebral vascular function and neuroprotection in ischemia. CNS Neurol Disord Drug Targets. 2013 May 1;12(3):316-24. doi: 10.2174/1871527311312030005. Review. PubMed PMID: 23469852.

Lin HW, Rundek T, Yoshida T. Letter by Lin et al regarding article, "Nitric oxide scavenging of red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion". Circulation. 2012 Feb 21;125(7):e384. doi: 10.1161/CIRCULATIONAHA.111.066100. PubMed PMID: 22354984.

Lin HW, Della-Morte D, Thompson JW, Gresia VL, Narayanan SV, Defazio RA, Raval AP, Saul I, Dave KR, Morris KC, Si ML, Perez-Pinzon MA. Differential effects of delta and epsilon protein kinase C in modulation of postischemic cerebral blood flow. Adv Exp Med Biol. 2012;737:63-9. doi: 10.1007/978-1-4614-1566-4_10. PubMed PMID: 22259083; PubMed Central PMCID: PMC4086166.

Lee RH, Liu YQ, Chen PY, Liu CH, Chen MF, Lin HW, Kuo JS, Premkumar LS, Lee TJ. Sympathetic α₃β₂-nAChRs mediate cerebral neurogenic nitrergic vasodilation in the swine. Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H344-54. doi: 10.1152/ajpheart.00172.2011. Epub 2011 May 2. PubMed PMID: 21536845.

Dave KR, Bhattacharya SK, Saul I, DeFazio RA, Dezfulian C, Lin HW, Raval AP, Perez-Pinzon MA. Activation of protein kinase C delta following cerebral ischemia leads to release of cytochrome C from the mitochondria via bad pathway. PLoS One. 2011;6(7):e22057. doi: 10.1371/journal.pone.0022057. Epub 2011 Jul 15. PubMed PMID: 21789211; PubMed Central PMCID: PMC3137627.

Lin HW, Thompson JW, Morris KC, Perez-Pinzon MA. Signal transducers and activators of transcription: STATs-mediated mitochondrial neuroprotection. Antioxid Redox Signal. 2011 May 15;14(10):1853-61. doi: 10.1089/ars.2010.3467. Epub 2011 Jan 5. Review. PubMed PMID: 20712401; PubMed Central PMCID: PMC3078497.

Morris KC, Lin HW, Thompson JW, Perez-Pinzon MA. Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning. J Cereb Blood Flow Metab. 2011 Apr;31(4):1003-19. doi: 10.1038/jcbfm.2010.229. Epub 2011 Jan 12. Review. PubMed PMID: 21224864; PubMed Central PMCID: PMC3070983.

Defazio RA, Levy S, Morales CL, Levy RV, Dave KR, Lin HW, Abaffy T, Watson BD, Perez-Pinzon MA, Ohanna V. A protocol for characterizing the impact of collateral flow after distal middle cerebral artery occlusion. Transl Stroke Res. 2011 Mar;2(1):112-27. doi: 10.1007/s12975-010-0044-2. PubMed PMID: 21593993; PubMed Central PMCID: PMC3095390.

Della-Morte D, Raval AP, Dave KR, Lin HW, Perez-Pinzon MA. Post-ischemic activation of protein kinase C ε protects the hippocampus from cerebral ischemic injury via alterations in cerebral blood flow. Neurosci Lett. 2011 Jan 7;487(2):158-62. doi: 10.1016/j.neulet.2010.10.013. Epub 2010 Oct 14. PubMed PMID: 20951185; PubMed Central PMCID: PMC3004991.

Lin HW, Defazio RA, Della-Morte D, Thompson JW, Narayanan SV, Raval AP, Saul I, Dave KR, Perez-Pinzon MA. Derangements of post-ischemic cerebral blood flow by protein kinase C delta. Neuroscience. 2010 Dec 1;171(2):566-76. doi: 10.1016/j.neuroscience.2010.08.058. Epub 2010 Sep 9. PubMed PMID: 20813167; PubMed Central PMCID: PMC2981031.

DeFazio RA, Raval AP, Lin HW, Dave KR, Della-Morte D, Perez-Pinzon MA. GABA synapses mediate neuroprotection after ischemic and epsilonPKC preconditioning in rat hippocampal slice cultures. J Cereb Blood Flow Metab. 2009 Feb;29(2):375-84. doi: 10.1038/jcbfm.2008.126. Epub 2008 Oct 29. PubMed PMID: 18957990; PubMed Central PMCID: PMC2696173.

Lin HW, Liu CZ, Cao D, Chen PY, Chen MF, Lin SZ, Mozayan M, Chen AF, Premkumar LS, Torry DS, Lee TJ. Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19526-31. doi: 10.1073/pnas.0810262105. Epub 2008 Dec 4. PubMed PMID: 19057014; PubMed Central PMCID: PMC2596137.

Della Morte D, Abete P, Gallucci F, Scaglione A, D'Ambrosio D, Gargiulo G, De Rosa G, Dave KR, Lin HW, Cacciatore F, Mazzella F, Uomo G, Rundek T, Perez-Pinzon MA, Rengo F. Transient ischemic attack before nonlacunar ischemic stroke in the elderly. J Stroke Cerebrovasc Dis. 2008 Sep;17(5):257-62. doi: 10.1016/j.jstrokecerebrovasdis.2008.03.004. PubMed PMID: 18755403; PubMed Central PMCID: PMC2676578.

Raval AP, Lin HW, Dave KR, Defazio RA, Della Morte D, Kim EJ, Perez-Pinzon MA. Resveratrol and ischemic preconditioning in the brain. Curr Med Chem. 2008;15(15):1545-51. doi: 10.2174/092986708784638861. Review. PubMed PMID: 18537630.

Invited Book Chapters 

  • Wu CY, Lee RHC, Lee MHH, Couto e Silva A, Hsieh THH, Possoit H, Brackett AL, Lin HW. (2017) Role of Neuroinflammation in Pathophysiology of Traumatic Brain Injury. In: Alireza Minagar (Ed.), Neuroinflammation (2nd ed.). Amsterdam, Netherlands: Elsevier Publishers Company. (Corresponding author)
  • Lee RHC, Wilkins CS, Couto e Silva, A, Valido SE, Wu, CY, Lin HW. (2014) Fatty Acids in Vascular Health. In: Lucas F. Porto (Ed.), Palmitic Acid: Occurrence, Biochemistry and Health Effects (1st ed.). Hauppauge, NY: Nova Science Publishers. (Corresponding author)
  • Dave KR, Thompson JW, Neumann JT, Perez-Pinzon MA, Lin HW. (2013) Neurovascular mechanisms of ischemia tolerance against brain injury. In: EH Lo, J Lok, MM Ning, MJ Whalen (Eds.), Vascular Mechanisms in CNS Trauma (1st ed.). NY, NY: Springer Publishing Company.
  • Narayanan SV, Morris-Blanco, KC, Perez-Pinzon MA, Lin HW. (2012). Ischemic preconditioning-mediated signaling pathways leads to tolerance against cerebral ischemia. In JM Gidday, MA Perez-Pinzon, & JH Zhang (Eds.), Innate Neuroprotection for Stroke (1st ed.). NY, NY: Springer Publishing Company. (Corresponding author)
  • Dave KR, Lin HW, Perez-Pinzon MA. (2012). Tolerance against global cerebral ischemia: experimental strategies, mechanisms and clinical applications. In JM Gidday, MA Perez-Pinzon, & JH Zhang (Eds.), Innate Neuroprotection for Stroke (1st ed.). NY, NY: Springer Publishing Company.
Powered by Create your own unique website with customizable templates.